From the Literature

Published: Dec 2015

Siegal DM, Curnutte JT, Connolly SJ, et al.

Andexanet alfa for the reversal of factor Xa inhibitor activity.
N Engl J Med 2015;373:2413-2424

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NATA REVIEW:
The direct factor Xa inhibitors apixaban and rivaroxaban are increasingly used for the prevention and the...
REVIEW by:
D. Faraoni

Published: Dec 2015

Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, et al.

Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children with severe anemia: the TOTAL randomized clinical trial.
JAMA 2015;314:2514-2523.

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NATA REVIEW:
Over the past few years, the "age of blood" has been one of the hot topics discussed regularly during meetings...
REVIEW by:
J. Meier

Published: Dec 2015

Ding YY, Kader B, Christiansen CL, Berlowitz DR

Hemoglobin level and hospital mortality among ICU patients with cardiac disease who received transfusions.
J Am Coll Cardiol 2015;66:2510-2518.

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NATA REVIEW:
This is an interesting investigation which serves to better inform healthcare providers in their clinical decision-making...
REVIEW by:
C. G. Koch

Published: Nov 2015

Refaai MA, Goldstein JN, Lee ML, Durn BL, Milling TJ, Jr., Sarode R

Increased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversal.
Transfusion 2015;55:2722-2729.

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NATA REVIEW:
Immediate reversal of the anticoagulant effect of vitamin K antagonists can be achieved by administration of...
REVIEW by:
M. Levi

Published: Oct 2015

Young P, Bailey M, Beasley R, et al.

Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial.
JAMA 2015;314:1701-1710.

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NATA REVIEW:
The SPLIT study, a double-bind, cluster randomised, double-crossover trial that was conducted in 4 ICUs...
REVIEW by:
M. Piagnerelli

Published: Oct 2015

Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM

Meta-analysis of the association between preoperative anaemia and mortality after surgery.
Br J Surg 2015;102:1314-1324.

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NATA REVIEW:
In this meta-analysis, Fowler et al. investigated the impact of preoperative anaemia on postoperative...
REVIEW by:
E. Bisbe

Published: Oct 2015

Sowers N, Froese PC, Erdogan M, Green RS

Impact of the age of stored blood on trauma patient mortality: a systematic review.
Can J Surg 2015;58:335-342.

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NATA REVIEW:
In this systematic review, Sowers et al. investigated the impact of the age of stored red blood cells...
REVIEW by:
S. R. Ostrowski

Published: Oct 2015

Al-Riyami AZ, Al-Khabori M, Baskaran B, Siddiqi M, Al-Sabti H

Intra-operative cell salvage in cardiac surgery may increase platelet transfusion requirements: a cohort study.
Vox Sang 2015;109:280-286.

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NATA REVIEW:
This article gives the results of an observational study that used a historical cohort of patients as a control...
REVIEW by:
D. Thomas

Published: Oct 2015

Johansson PI, Rasmussen AS, Thomsen LL

Intravenous iron isomaltoside 1000 (Monofer(®)) reduces postoperative anaemia in preoperatively non-anaemic patients undergoing elective or subacute coronary artery bypass graft, valve replacement or a combination thereof: the PROTECT trial
Vox Sang 2015;109:257-266.

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NATA REVIEW:
This prospective double-blind placebo-controlled randomised single-centre trial reports that, in non-anaemic...
REVIEW by:
P. Van der Linden

Published: Sep 2015

Hunt BJ, Allard S, Keeling D, Norfolk D, Stanworth SJ, Pendry K

A practical guideline for the haematological management of major haemorrhage.
Br J Haematol 2015;170:788-803.

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NATA REVIEW:
Hunt et al. set the standards in a practical guideline from the British Committee for Standards in Haematology....
REVIEW by:
J. Stensballe

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