From the Literature

Published: Feb 2015

Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management.
Anesthesiology 2015;122:241-275.

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NATA REVIEW:
These Practice Guidelines update “Practice Guidelines for Perioperative Blood Transfusion and Adjuvant Therapies:...
REVIEW by:
J.-F. Hardy

Published: Feb 2015

Bouet PE, Ruiz V, Legendre G, Gillard P, Descamps P, Sentilhes L

High-dose tranexamic acid for treating postpartum haemorrhage after vaginal delivery.
Br J Anaesth 2015;114:339-341.

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NATA REVIEW:
This report describes 60 women given high-dose tranexamic acid (4 g) if they sustained >800 mL...
REVIEW by:
B. J. Hunt

Published: Feb 2015

Guzzetta NA, Allen NN, Wilson EC, Foster GS, Ehrlich AC, Miller BE

Excessive postoperative bleeding and outcomes in neonates undergoing cardiopulmonary bypass.
Anesth Analg 2015;120:405-410.

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NATA REVIEW:
Children undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at increased risk for postoperative...
REVIEW by:
D. Faraoni

Published: Feb 2015

Hoffman M, Volovyk Z, Monroe DM

Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate.
Anesthesiology 2015;122:353-362.

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NATA REVIEW:
Dabigatran is a direct thrombin inhibitor increasingly used for the prevention and treatment of thromboembolism....
REVIEW by:
D. Faraoni

Published: Feb 2015

Herzog E, Kaspereit F, Krege W, et al.

Effective reversal of edoxaban-associated bleeding with four-factor prothrombin complex concentrate in a rabbit model of acute hemorrhage.
Anesthesiology 2015;122:387-398.

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NATA REVIEW:
New-generation oral anticoagulants, specifically targeted at thrombin or factor Xa, have been shown to be effective...
REVIEW by:
M. Levi

Published: Feb 2015

Reed GW, Kumar A, Guo J, et al.

Point-of-care platelet function testing predicts bleeding in patients exposed to clopidogrel undergoing coronary artery bypass grafting: Verify Pre-Op TIMI 45 – a pilot study.
Clin Cardiol 2015;38:92-98.

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NATA REVIEW:
The authors performed a proof-of-principle pilot study indicating that point-of-care platelet function testing...
REVIEW by:
S. Kozek-Langenecker

Published: Jan 2015

Graham DJ, Reichman ME, Wernecke M, et al.

Cardiovascular, bleeding, and mortality risks in elderly medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation.
Circulation 2015;131:157-164.

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NATA REVIEW:
We have entered a new era with novel oral anticoagulants specifically targeted at thrombin (e.g. dabigatran)...
REVIEW by:
M. Levi

Published: Jan 2015

Godier A, Taylor G, Gaussem P

Inefficacy of platelet transfusion to reverse ticagrelor.
N Engl J Med 2015;372:196-197.

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NATA REVIEW:
Godier and colleagues describe a patient on dual antiplatelet therapy with ticagrelor and aspirin due to two...
REVIEW by:
P. Johansson

Published: Jan 2015

Zahir H, Brown KS, Vandell AG, et al.

Edoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrate.
Circulation 2015;131:82-90.

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NATA REVIEW:
Edoxaban is a non-vitamin K oral anticoagulant (NOAC) that directly inhibits factor Xa. The efficacy and...
REVIEW by:
D. Faraoni

Published: Jan 2015

Nakayama Y, Nakajima Y, Tanaka KA, et al.

Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery.
Br J Anaesth 2015;114:91-102.

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NATA REVIEW:
Over the past decade, viscoelastic tests have been increasingly used in different clinical settings. Although...
REVIEW by:
D. Faraoni

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