From the Literature

Published: Mar 2015

Lasocki S, Krauspe R, von Heymann C, Mezzacasa A, Chainey S, Spahn DR

PREPARE: the prevalence of perioperative anaemia and need for patient blood management in elective orthopaedic surgery: A multicentre, observational study.
Eur J Anaesthesiol 2015;32:160-167.

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NATA REVIEW:
In this observational, multicentre study, the authors investigated the prevalence of pre- and postoperative anaemia...
REVIEW by:
E. Bisbe

Published: Mar 2015

Karkouti K, McCluskey SA, Callum J, et al.

Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis.
Anesthesiology 2015;122:560-570.

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NATA REVIEW:
The authors evaluated a novel transfusion algorithm that uses point-of-care coagulation testing. They enrolled...
REVIEW by:
J.-F. Hardy

Published: Feb 2015

Holcomb JB, Tilley BC, Baraniuk S, et al.

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
JAMA 2015;313:471-482.

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NATA REVIEW:
Holcomb and colleagues lead the way in high-quality trauma resuscitation research, setting the standard for...
REVIEW by:
J. Stensballe

Published: Feb 2015

Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management.
Anesthesiology 2015;122:241-275.

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NATA REVIEW:
These Practice Guidelines update “Practice Guidelines for Perioperative Blood Transfusion and Adjuvant Therapies:...
REVIEW by:
J.-F. Hardy

Published: Feb 2015

Guzzetta NA, Allen NN, Wilson EC, Foster GS, Ehrlich AC, Miller BE

Excessive postoperative bleeding and outcomes in neonates undergoing cardiopulmonary bypass.
Anesth Analg 2015;120:405-410.

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NATA REVIEW:
Children undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at increased risk for postoperative...
REVIEW by:
D. Faraoni

Published: Feb 2015

Hoffman M, Volovyk Z, Monroe DM

Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate.
Anesthesiology 2015;122:353-362.

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NATA REVIEW:
Dabigatran is a direct thrombin inhibitor increasingly used for the prevention and treatment of thromboembolism....
REVIEW by:
D. Faraoni

Published: Feb 2015

Herzog E, Kaspereit F, Krege W, et al.

Effective reversal of edoxaban-associated bleeding with four-factor prothrombin complex concentrate in a rabbit model of acute hemorrhage.
Anesthesiology 2015;122:387-398.

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NATA REVIEW:
New-generation oral anticoagulants, specifically targeted at thrombin or factor Xa, have been shown to be effective...
REVIEW by:
M. Levi

Published: Feb 2015

Reed GW, Kumar A, Guo J, et al.

Point-of-care platelet function testing predicts bleeding in patients exposed to clopidogrel undergoing coronary artery bypass grafting: Verify Pre-Op TIMI 45 – a pilot study.
Clin Cardiol 2015;38:92-98.

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NATA REVIEW:
The authors performed a proof-of-principle pilot study indicating that point-of-care platelet function testing...
REVIEW by:
S. Kozek-Langenecker

Published: Feb 2015

Bouet PE, Ruiz V, Legendre G, Gillard P, Descamps P, Sentilhes L

High-dose tranexamic acid for treating postpartum haemorrhage after vaginal delivery.
Br J Anaesth 2015;114:339-341.

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NATA REVIEW:
This report describes 60 women given high-dose tranexamic acid (4 g) if they sustained >800 mL...
REVIEW by:
B. J. Hunt

Published: Jan 2015

Graham DJ, Reichman ME, Wernecke M, et al.

Cardiovascular, bleeding, and mortality risks in elderly medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation.
Circulation 2015;131:157-164.

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NATA REVIEW:
We have entered a new era with novel oral anticoagulants specifically targeted at thrombin (e.g. dabigatran)...
REVIEW by:
M. Levi

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