From the Literature

Published: Feb 2015

Hoffman M, Volovyk Z, Monroe DM

Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate.
Anesthesiology 2015;122:353-362.

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NATA REVIEW:
Dabigatran is a direct thrombin inhibitor increasingly used for the prevention and treatment of thromboembolism....
REVIEW by:
D. Faraoni

Published: Feb 2015

Herzog E, Kaspereit F, Krege W, et al.

Effective reversal of edoxaban-associated bleeding with four-factor prothrombin complex concentrate in a rabbit model of acute hemorrhage.
Anesthesiology 2015;122:387-398.

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NATA REVIEW:
New-generation oral anticoagulants, specifically targeted at thrombin or factor Xa, have been shown to be effective...
REVIEW by:
M. Levi

Published: Feb 2015

Reed GW, Kumar A, Guo J, et al.

Point-of-care platelet function testing predicts bleeding in patients exposed to clopidogrel undergoing coronary artery bypass grafting: Verify Pre-Op TIMI 45 – a pilot study.
Clin Cardiol 2015;38:92-98.

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NATA REVIEW:
The authors performed a proof-of-principle pilot study indicating that point-of-care platelet function testing...
REVIEW by:
S. Kozek-Langenecker

Published: Feb 2015

Bouet PE, Ruiz V, Legendre G, Gillard P, Descamps P, Sentilhes L

High-dose tranexamic acid for treating postpartum haemorrhage after vaginal delivery.
Br J Anaesth 2015;114:339-341.

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NATA REVIEW:
This report describes 60 women given high-dose tranexamic acid (4 g) if they sustained >800 mL...
REVIEW by:
B. J. Hunt

Published: Jan 2015

Graham DJ, Reichman ME, Wernecke M, et al.

Cardiovascular, bleeding, and mortality risks in elderly medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation.
Circulation 2015;131:157-164.

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NATA REVIEW:
We have entered a new era with novel oral anticoagulants specifically targeted at thrombin (e.g. dabigatran)...
REVIEW by:
M. Levi

Published: Jan 2015

Godier A, Taylor G, Gaussem P

Inefficacy of platelet transfusion to reverse ticagrelor.
N Engl J Med 2015;372:196-197.

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NATA REVIEW:
Godier and colleagues describe a patient on dual antiplatelet therapy with ticagrelor and aspirin due to two...
REVIEW by:
P. Johansson

Published: Jan 2015

Zahir H, Brown KS, Vandell AG, et al.

Edoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrate.
Circulation 2015;131:82-90.

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NATA REVIEW:
Edoxaban is a non-vitamin K oral anticoagulant (NOAC) that directly inhibits factor Xa. The efficacy and...
REVIEW by:
D. Faraoni

Published: Jan 2015

Müller MC, Arbous MS, Spoelstra-de Man AM, et al.

Transfusion of fresh-frozen plasma in critically ill patients with a coagulopathy before invasive procedures: a randomized clinical trial.
Transfusion 2015;55:26-35.

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NATA REVIEW:
This multicentre randomised non-inferiority trial was conducted for assess whether critically ill patients with...
REVIEW by:
S. R. Leal-Noval

Published: Jan 2015

Bailie GR, Larkina M, Goodkin DA, et al.

Data from the Dialysis Outcomes and Practice Patterns Study validate an association between high intravenous iron doses and mortality.
Kidney Int 2015;87:162-168.

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NATA REVIEW:
This is a very well done and important work. Bailie and co-authors stratified chronic kidney disease populations...
REVIEW by:
M. Auerbach

Published: Jan 2015

Spiegelstein D, Holmes SD, Pritchard G, Halpin L, Ad N

Preoperative hematocrit as a predictor of perioperative morbidities following nonemergent coronary artery bypass surgery.
J Card Surg 2015;30:20-26.

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NATA REVIEW:
This retrospective analysis of prospectively collected data reports that, among 2300 patients undergoing...
REVIEW by:
P. Van der Linden

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