21st Annual NATA Symposium
The 21st Annual NATA Symposium on Patient Blood Management, Haemostasis and Thrombosis will take place on April 23-24, 2020 in Athens, Greece.
Please click on the link below for more information
21st Annual Symposium General Information
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News from the Industry
New clinical data support efficacy of fibrinogen concentrate (fibryga®) in treating acquired fibrinogen deficiency and lead to label extension in Europe
Fibrinogen replacement is widely accepted as an approach to managing acquired fibrinogen deficiency (AFD) in patients with critical bleeding, despite a lack of evidence until now from controlled clinical studies. Data from two comparative studies with Octapharma's highly-purified, dual pathogen-inactivated fibrinogen concentrate fibryga® have recently been published, and provide robust clinical support for this treatment approach.
The outcomes of a randomised, controlled clinical trial investigating approaches to bleeding control during cytoreductive surgery in 55 patients with pseudomyxoma peritonei were presented at the ISTH 2019 Congress in July. Fibrinogen replacement was effective for treatment of AFD in all cases, as measured by overall haemostatic efficacy. The results demonstrated non-inferiority of fibryga® (n = 22) compared with cryoprecipitate (n = 23) (p < 0.0095 for non-inferiority).
More recently, data from the first large multicentre, randomised controlled trial in AFD were published (JAMA, 2019). In a study of 827 patients undergoing cardiac surgery, fibryga® met the non-inferiority endpoint compared with cryoprecipitate (p < 0.001 for non-inferiority). Safety profiles of fibryga® and cryoprecipitate were comparable. Based on these clinical data, fibryga® received approval in the European Union for treatment of acquired fibrinogen deficiencies.
Read more at www.fibrinogendeficiency.com.
News
Patient Blood Management is not about blood transfusion: it is about patients' outcomes
"We can only agree with some of the recommendations put forward by the 2018 Frankfurt Consensus Conference, the authors write, but we feel that a true consensus between blood bankers, clinicians well-versed in the management of patients undergoing major surgery at risk of bleeding and researchers in the field would have sent a stronger and more relevant message in favour of PBM."
"PBM is not an offensive against producers of blood components. PBM aims to improve the outcomes of patients at risk through the optimisation of the patient's condition before, during and after the procedure."
Read more on this
Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement
The aim of this multidisciplinary consensus statement, published online ahead of print in Blood Transfusion on February 6, 2019, is to provide recommendations on the prevention and treatment of postpartum haemorrhage as part of patient blood management in obstetrics.
It was developed by NATA in collaboration with the International Federation of Gynaecology and Obstetrics (FIGO), the European Board and College of Obstetrics and Gynaecology (EBCOG) and the European Society of Anaesthesiology (ESA).
Read more on this
From the Literature
Published: Dec 2019
Kaserer A, Rössler J, Braun J, et al.
Impact of a Patient Blood Management monitoring and feedback programme on allogeneic blood transfusions and related costs.
Published: Nov 2019
Bah A, Muhammad AK, Wegmuller R, et al.
Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia.
Published: Nov 2019
CRASH-3 trial collaborators
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial.
Published: Nov 2019
Harenberg J, Beyer-Westendorf J, Crowther M, et al.
Accuracy of a rapid diagnostic test for the presence of direct oral factor Xa or thrombin inhibitors in urine – a multicenter trial.
Published: Nov 2019
Ming Y, Liu J, Zhang F, et al.
Transfusion of red blood cells, fresh frozen plasma, or platelets is associated with mortality and infection after cardiac surgery in a dose-dependent manner.
Published: Nov 2019
Raphael J, Mazer CD, Subramani S, et al.
Society of Cardiovascular Anesthesiologists clinical practice improvement advisory for management of perioperative bleeding and hemostasis in cardiac surgery patients.