Pharmacokinetics and safety of FFR-rFVIIa after single doses in healthy subjects.
This is a double-blind placebo controlled dose escalation trial evaluating efficacy and safety of inactivated rFVIIa (FFR-rFVIIa) as an antithrombotic agent. The trial showed a dose dependent prolongation of the prothrombin time. Future studies in patients undergoing vascular intervention are required. – M. Aldouri. FFR-rFVIIa is a variant activated factor VII molecule that is characterised […]
Heparin coating of the extracorporeal circuit combined with leukocyte filtration reduces coagulation activity, blood loss and blood product substitution.
Heparin bonded circuits have become standard in extracorporeal bypass circuits for open heart surgery. Leukoreduction of allogeneic red blood cells is also considered a standard of care in many countries. Martens and colleagues concluded from this small series of patients that the addition of a leukocyte filter to the heparin bonded circuit is associated with […]
Randomized comparison of ultrasonic vs clamp transection of the liver.
Takayama and his colleagues show us another step forward in the development of optimal techniques for liver resection. Their message emphasizes that the skill of the surgeon remains critical in choosing the right instrumentation for surgery. R. K. Spence.
