Hemoglobin-vesicles as oxygen carriers – Influence on phagocytic activity and histopathological changes in reticuloendothelial system.

Sakai H, Horinouchi H, Tomiyama K, et al.
Am J Pathol 2001;159(3):1079-1088.
Review by : J.-F. Hardy
NATA Review
A good basic science article demonstrating that a single dose of hemoglobin encapsulated in a phospholipid bilayer membrane injected in rats has a transient and acceptable effect on the reticuloendothelial system. Initially, the RES is depressed but function returns to normal as hemoglobin vesicles are cleared. Questions that remain relate to the effect of hemoglobin vesicles in humans, repeated administration of the product and the use of higher, more clinically relevant doses.

– J.-F. Hardy.