Aug
2001

Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial.

Vichinsky EP, Luban NLC, Wright E, et al.
Transfusion 2001;41(9):1086-1092.
Review by : V. Kretschmer.
NATA Review
For a transfusionist from West/North Europe, the results are predictable and the conclusion expectable. In Germany, the prospective RBC phenotype matching in sickle cell anemia and thalassemia, and even in patients with chronic anemia, has been performed for many years (at least for C, c, E, e, K) and does not pose major problems. It is surprising that it should be
necessary to show that it can be implemented nationwide and that immunization can be significantly reduced in polytransfused patients.

– V. Kretschmer.