A single high dose of recombinant factor VIIa combining adjuvant therapy for controlling bleeding episodes in haemophiliacs with inhibitors.

A single dose of rFVIIa (150-180 μg/kg) was used to treat five muscle/joint bleeds and to cover 4 minor surgical procedures in 2 patients with hemophilia A and one with hemophilia B with inhibitors. Patients also received prednisolone, in addition to using fibrin glue, dental splint and tranexamic acid with surgical procedures. Treatment was either partially effective or effective in all patients, with better response in surgical prophylaxis.

– M. Aldouri.