A double-blind study to evaluate the safety of recombinant human hemoglobin in surgical patients during general anesthesia.

Hayes JK, Stanley TH, Lind GH, East K, Smith B, Kessler K
J Cardiothorac Vasc Anesth 2001;15(5):593-602.
NATA Rating :
Review by : Ph. Van der Linden
NATA Review
The authors evaluated the safety profile of escalating doses of rHb1.1 in patients undergoing surgery under general anesthesia. The adverse effects observed (and the authors’ conclusions) are those that one would expect for this type of product. Unfortunately, it appears that we have not yet found the Holy Grail of hemoglobin replacement therapy…

– J.-F. Hardy.

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