Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine.

Manning JE, Katz LM, Pearce LB, et al.
Crit Care Med 2001;29(11):2067-2074.
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The important message in this case is that a hemoglobin-based oxygen carrier was able to restore viable cardiovascular function after exsanguinating cardiac arrest in a swine model of liver injury with profound hemorrhagic shock. Nonetheless, the reader is left with many questions. What effect(s) of the hemoglobin solution was responsible for the favorable outcome observed―a vasopressor effect or increased oxygen transport? How feasible is SAAP in patients with blunt traumatic cardiac arrest?

– J.-F. Hardy.

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