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This article starts with a general overview on mechanism of action, uses and safety of rFVIIa as well as the hemostatic disorders which are associated with liver disease. It states the correlation between the degree of liver damage and level and gene expression of FVII. The authors reviewed the use of rFVIIa in liver disease which showed correlation between dosage and level of FVII as well as reduction of APTT. RFVIIa was used effectively in patients with liver disease to cover cataract surgery, liver biopsy and in treating bleeding oesophageal varices.
– M. Aldouri.