Jan
2002

Successful use of recombinant factor VIIa for hemostasis during total knee replacement in a severe hemophiliac with high-titer factor VIII inhibitor.

Carr ME, Loughran TP, Cardea JA, Smith WK, Kuhn JG, Dottore MV
Int J Hematol 2002;75(1):95-99.
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This is another case report of a successful use of rFVIIa in covering knee replacement surgery in a patient with severe hemophilia A and high-titer inhibitor. rFVIIa was given at a dose of 85 u/kg at 2-hourly interval initially, increasing the interval between infusions every 48 hours. Effective hemostasis was achieved. The authors recommend administering a dose of rFVIIa prior to removing the tourniquet and to initiate early post-operative aggressive physiotherapy when the level of factor VII is high.

– M. Aldouri.