Mar
2002

Acquired factor VII deficiency in hematopoietic stem cell transplant recipients.

Toor AA, Slungaard A, Hedner U, Weisdorf DJ, Key NS
Bone Marrow Transplant 2002;29(5):403-408.
NATA Rating :
Review by : Aldouri M
NATA Review
This is an interesting and new case report on the occurrence of acquired factor VII deficiency in eight patients following intensive chemotherapy and/or radiotherapy followed by hematopoietic stem cell transplantation (SCT), associated with serious and sometimes fatal hemorrhagic complications with poor response to transfusion of blood components. Tests for antibodies against FVII were negative. It is postulated that the etiology of FVII deficiency was accelerated clearance of FVII. Acquired FVII deficiency should be considered in patients with prolonged prothrombin time who have undergone SCT
or have been recently treated with cytoreductive therapy.

– M. Aldouri.