Efficacy of recombinant factor VIIa administered by continuous infusion to haemophilia patients with inhibitors.

Mauser-Bunschoten EP, Koopman MMW, Goede-Bolder ADE, et al.
Haemophilia 2002;8(5):649-656.
NATA Rating :
Review by : M. Aldouri
NATA Review
This is an interesting study looking at the efficacy of administering rFVIIa in controlling bleeding in 43 episodes in 14 hemophilia patients with inhibitors. RFVIIa infusion was not effective in controlling oral bleeding, but effective in controlling bleeding in other sites. The authors postulate that rFVIIa infusion was not effective in activating thrombin activatable fibrinolysis inhibitor (TAFI) which is required to inhibit fibrinolytic activity which is high in the oral cavity.

– M. Aldouri