– Philippe Van der Linden
This is a second article on the effect of HBOC-201 for the acute treatment of hemorrhagic shock in swine. In this model, 7 swines were submitted to hemorrhagic shock and the sequence of the experiment was designed to reproduce out-of-hospital resuscitation. A small dose (6 mL/kg) of HBOC-201 improved cardiac output and mean arterial pressure. More importantly, brain tissue oxygen tension was not only restored but surpassed baseline values by 66%.
We can only hope that these favorable results will be reproduced, eventually, in humans.
– Jean-Franois Hardy