May
2002

Use of recombinant factor Vlla (NovoSeven((R))) to reduce postoperative bleeding after total hip arthroplasty in a patient with cirrhosis and thrombocytopenia.

Slappendel R, Huvers FC, Benraad B, Novakova I, van Hellemondt GG
Anesthesiology 2002;96(6):1525-1527.
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The role of rFVIIa in improving hemostasis in patients with chronic liver disease and/or thrombocytopenia has been reported in many case reports. This article is reporting a 59 yr old woman with liver cirrhosis and thrombocytopenia who suffered with profuse bleeding post total hip replacement. The patient was receiving red cell reinfusion using a cell saver. Bleeding was significantly reduced after administration of a single dose of rFVIIa at 100 μg/kg.

– Maadh Aldouri