Nov
2002

The in vitro effects of crystalloids and colloids on coagulation.

Ekseth K, Abildgaard L, Vegfors M, Berg-Johnsen J, Engdahl O
Anaesthesia 2002;57(11):1102-1108.
NATA Rating :
Review by : Mythen MG; Baron JF
NATA Review
Worth a close look for those with a specialist interest in this area. Adds to a fast growing body of literature on the various effects of i.v. solutions on coagulation in-vitro. We wait with baited breath for the clinical studies.

– Monty Mythen

There are two major disturbing points about this article. Firstly, the main effect of some colloids is to increase the elimination of coagulation factors; therefore, it is absolutely compulsory to make in vivo studies. Secondly, no mention is made of the type of HES being studied.

– Jean-Franois Baron