Increased local procoagulant action: a mechanism contributing to the favorable hemostatic effect of recombinant FVIIa in PLT disorders.

This paper reports the procoagulant effect of rFVIIa in experimental thrombocytopenia, and in thromboasthenic platelets due to natural or experimentally induced glycoprotein deficiency. It shows that rFVIIa improved fibrin deposition, thrombin generation and platelet interaction at sites of vascular damage. These observations may explain the hemostatic effects of rFVIIa in controlling hemorrhage in patients with qualitative and quantitative platelet disorders.

– Maadh Aldouri