Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A.

Tranholm M, Kristensen K, Kristensen AT, Pyke C, Rojkjaer R, Persson E
Blood 2003;102(10):3615-3620.
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This is an elegant paper which studied the hemostatic efficacy of different doses of rFVIIa and three of its analogs on controlling bleeding in mice with antibody induced hemophilia. There was significant decrease in blood loss, bleeding time, PT and APTT in the treated animals. rFVIIa analogs were 3-4 times more potent than rFVIIa, and their mechanism of action was thought to be independent of tissue factor. There were no reported side effects from treatment, and no pathological changes in the mice kidneys.

– Maadh Aldouri