May
2003

Perflubron emulsion in prolonged hemorrhagic shock: influence on hepatocellular energy metabolism and oxygen-dependent gene expression.

Paxian M, Rensing H, Geckeis K, et al.
Anesthesiology 2003;98(6):1391-1399.
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This experimental study, using quite sophisticated methods, demonstrates that a perfluorocarbon emulsion together with a high FiO2 is able to improve oxygen availability to the liver as compared to stored whole blood or colloids during prolonged hemorrhagic shock. This is another contribution to the increased evidence that, like hemoglobin solutions, perfluorocarbon solutions are not blood substitutes but could be considered “oxygen therapeutics”.

– Philippe Van der Linden
and Jean-Franois Hardy