May
2004

The use of recombinant factor VIIa for severe intractable bleeding during spine surgery.

Kaw LL, Jr., Coimbra R, Potenza BM, Garfin SR, Hoyt DB
Spine 2004;29(12):1384-1387.
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This is a report on the effective use of rFVIIa in controlling postoperative surgical bleeding and coagulopathy in four patients who underwent multilevel spine surgery. Bleeding was not initially controlled with the use of local measures and transfusion of blood components. Three patients required a single dose, and one received 2 doses. RFVIIa doses ranged from 16-117 mcg/kg body weight. There was no recurrence of bleeding or occurrence of thrombotic complications. Authors conclude that rFVIIa is effective in controlling postoperative bleeding in spine surgery.

– Maadh Aldouri