May
2004

Recombinant human hemoglobin with reduced nitric oxide-scavenging capacity restores effectively pancreatic microcirculatory disorders in hemorrhagic shock.

von Dobschuetz E, Hutter J, Hoffmann T, Messmer K
Anesthesiology 2004;100(6):1484-1490.
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A recombinant hemoglobin based oxygen carrier with reduced nitric oxide-scavenging properties through site directed mutagenesis of the heme pocket has been developed. This second-generation product has been shown to be an effective resuscitation fluid restoring pancreatic microcirculation in a rat model of hemorrhagic shock. Unfortunately, the future development of such compound appears compromised due to financial problems.

– Philippe Van der Linden