May
2005

Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants.

Bell EF, Strauss RG, Widness JA, et al.
Pediatrics 2005;115(6):1685-1691.
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Thoroughly and conscientiously performed randomized controlled study investigating the effect of restrictive versus liberal
transfusion of red blood cells in preterm infants. The data confirm a significant reduction of the number of transfused red blood cell units with a restrictive transfusion strategy. However, the infants in the restrictive transfusion group were more likely to
suffer major adverse neurologic events and had more frequent apnea.

– Volker Kretschmer