Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants.

Thoroughly and conscientiously performed randomized controlled study investigating the effect of restrictive versus liberal
transfusion of red blood cells in preterm infants. The data confirm a significant reduction of the number of transfused red blood cell units with a restrictive transfusion strategy. However, the infants in the restrictive transfusion group were more likely to
suffer major adverse neurologic events and had more frequent apnea.

– Volker Kretschmer