Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials.

The etiology of severe hemorrhage associated with trauma includes coagulopathy, hypothermia, acidosis, as well as platelet dysfunction, in addition to the direct effect of trauma itself. This important large international randomized placebo controlled study in blunt and penetrating trauma showed a significant reduction in blood transfusion requirement in patients with blunt trauma who received rFVIIa, […]

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