Jul
2005

Recombinant factor VIIa in the treatment of intractable bleeding in vascular surgery.

Manning BJ, Hynes N, Courtney DF, Sultan S
Eur J Vasc Endovasc Surg 2005 Aug 12; [Epub ahead of print].
NATA Rating :
Review by : M. Aldouri
NATA Review

This is a small series of case reports on using rFVIIa in treating severe perioperative hemorrhage in 8 patients undergoing major vascular surgeries, contributing to effective hemostasis in 7 of them. There were 2 early deaths but post mortem examination revealed no evidence for thromboembolic events. It was concluded that rFVIIa is effective in controlling excessive bleeding associated with such surgeries, especially if used early in the course of therapy before massive transfusion is administered.

– Maadh Aldouri