May
2009

Rejuvenation treatment of stored red blood cells reverses storage-induced adhesion to vascular endothelial cells.

Koshkaryev A, Zelig O, Manny N, Yedgar S, Barshtein G
Transfusion 2009; Jun 15 [Epub ahead of print].
NATA Rating :
Review by : R. Moog
NATA Review

Koshkaryev and co-workers have studied a rejuvenation solution for RBCs for their ability to adhere to vascular endothelial cells in vitro. Stored RCs and freshly donated RBCs were used as controls. Stored RBCs loose their function over the storage time up to 7 weeks due to the storage lesion. Rejuvenation of RBCs has been studied for more than 20 years to improve RBC function but studies have shown only limited success. The presented paper is an interesting in vitro approach to show the superiority of rejuvenated RBCs but it lacks clinical significance.

– Rainer Moog