Dec
2009

HES130/0.4 impairs haemostasis and stimulates pro-inflammatory blood platelet function.

Sossdorf M, Marx S, Schaarschmidt B, et al.
Crit Care 2009;13(6):R208.
NATA Rating :
Review by : S. Kozek-Langenecker
NATA Review

The present in vitro study entertains doubts: CD62P expression increased at 40% HES dilution previous studies had found an antiplatelet effect, especially for penta- and hetastarch. Formation of heterotypic cell conjugates also increased with an inverse dose-dependence and high standard error of mean previous studies had revealed that tetrastarch possesses anti-inflammatory effects. Experimental artefacts or clinical relevance?

– Sybille Kozek-Langenecker