Dose of prophylactic platelet transfusions and prevention of hemorrhage.

Slichter SJ, Kaufman RM, Assmann SF, et al.
N Engl J Med 2010;362(7):600-613.
NATA Rating :
Review by : P. Rebulla
NATA Review

This highly powered clinical trial compared the effect of prophylactic platelet transfusion at three platelet doses on grade 2 or greater bleeding in 1,272 thrombocytopenic recipients affected by hematologic conditions. The study showed no effect on bleeding incidence at doses between 1.1 and 4.4 x 10e11 per recipient body surface square meter.

– Paolo Rebulla

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