To continue or discontinue aspirin in the perioperative period: a randomized, controlled clinical trial.

Oscarsson A, Gupta A, Fredrikson M, et al.
Br J Anaesth 2010;104(3):305-312.
NATA Rating :
Review by : C.-M. Samama
NATA Review

This randomized double-blind study compared perioperative maintenance with the preoperative withdrawal of aspirin 7 days before non-cardiac surgery in high-risk patients. Aspirin maintenance allows a 80% decrease in the relative risk for major adverse cardiac events, without increasing bleeding complications. This study is probably underpowered because only 220 patients were included; however it confirms for the first time the validity of a widely used clinical practice.

– Charles-Marc Samama

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