Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.

Henry DA, Carless PA, Moxey AJ, et al.

Cochrane Database Syst Rev 2011;(3):CD001886.

NATA Rating :
Review by : J.-F. Hardy
NATA Review

This review does not present new data for those who are familiar with the use of antifibrinolytics in the perioperative setting. It constitutes, however, a very useful summary of the current situation regarding these drugs. In practice, tranexamic acid is the only antifibrinolytic available in a majority of centers. While it appears to be safe, more studies will be required to confirm the absence of side effects such as convulsions (at higher doses) or thromboembolic events.

– Jean-François Hardy

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