This article is well written and the statistics are good, but the study includes a small number of patients and is nonrandomized. The results add to the old debate about the possible hemostatic use of fibrin glue. The authors report no statistical benefit of applying this method in patients undergoing total knee replacement, which is also the result of many other studies. I think it offers very modest benefits in clinical practice. Only a future study conducted in a randomized fashion and including a greater number of patients will be able to give more precise information on the hemostatic benefits of fibrin glue in this type of surgical procedures. – Constantine Vagianos