A prospective randomized study comparing fibrin sealant to manual compression for the treatment of anastomotic suture-hole bleeding in expanded polytetrafluoroethylene grafts.

Saha SP, Muluk S, Schenk W, 3rd, et al.
J Vasc Surg 2012;56:134-141.
NATA Rating :
Review by : C. Vagianos
NATA Review

This is a well-written and well-designed prospective multicenter study evaluating the hemostatic effect of fibrin sealant on vascular anastomoses. A significantly better control of bleeding was shown when using fibrin sealant, compared to 4 minutes of manual pressure. A reasonable argument would then be: why only 4 minutes of manual compression and not, for example, 6 or 8? Is the cost of fibrin glue less than prolonging the operation by a few minutes? I believe this is a paper worth reading, but that it will not really change clinical practice.

– Constantine Vagianos

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