The influence of bleeding on trigger changes for platelet transfusion in patients with chemotherapy-induced thrombocytopenia.
This study shows that clinicians change the platelet transfusion trigger of 10 x 10(9)/L, a current standard for bleeding prophylaxis in hyporegenerative thrombocytopenia, in the majority of patients during their hospitalization. They do so more frequently in recipients of an allogeneic hemopoietic transplant compared to patients on chemotherapy or autologous transplant. These findings suggest that different triggers should be defined for different categories of hypoproliferative thrombocytopenic patients and call for guidance to clinicians on trigger changes before bleeding occurs.
– Paolo Rebulla