Tranexamic acid for cesarean section: a double-blind, placebo-controlled, randomized clinical trial.

Senturk MB, Cakmak Y, Yildiz G, Yildiz P
Arch Gynecol Obstet 2013;287:641-645.
NATA Rating :
Review by : B. J. Hunt
NATA Review

The authors assessed the use of 1 g tranexamic acid (TA) versus placebo in elective cesarean section in 223 women. The endpoint was the perioperative fall in hemoglobin, which was less in those receiving TA: Hb difference 1.11 ±  0.62 g/dL in those who received TA versus 1.27 ±  0.66 g/dL in the controls (p =  0.034). No adverse effects were seen. However, the study design was imperfect.

– Beverley J. Hunt