Feb
2013

Effect of waxy maize-derived hydroxyethyl starch 130/0.4 on renal function in surgical patients.

Martin C, Jacob M, Vicaut E, Guidet B, Van Aken H, Kurz A
Anesthesiology 2013;118:387-394.
NATA Rating :
Review by : P. Van der Linden
NATA Review

This meta-analysis included 17 studies (1230 patients) that evaluated the renal effects of 6% waxy maize-derived hydroxyethyl starch 130/0.4 (in 0.9% NaCl) in surgical patients, with the exception of patients undergoing renal transplantation. The authors found no evidence of a possible association between the administration of this modern starch solution and changes of serum creatinine, calculated creatinine clearance and incidence of acute renal failure and renal replacement therapy in this patient population. These results emphasize once again that results observed in the critical care setting should not be extrapolated to the surgical population.

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– Philippe Van der Linden