Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women–PREFER a randomized, placebo-controlled study.

Favrat B, Balck K, Breymann C, et al.
PLoS One 2014;9:e94217.
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Review by : L. T. Goodnough
NATA Review

The authors studied the value of intravenous iron supplementation in a cohort of women with a diagnosis of iron deficiency but who were not yet anaemic. In this controlled clinical trial, the intravenous iron therapy cohort had significant improvement in fatigue, quality of life, and cognitive function when compared to the placebo-treated cohort. These results establish for the first time the importance of iron replacement therapy to address patient symptoms due to iron deficiency, independent of the development of anaemia and its own related symptoms.

– Lawrence Tim Goodnough

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