Efficacy and safety of fibrinogen concentrate in trauma patients–a systematic review.

Aubron and colleagues performed a systematic review of the use of fibrinogen concentrate in trauma and identified 4 case reports, 7 retrospective studies and 1 prospective observational study, of which three (2 retrospective studies and the prospective observational study) were not restricted to trauma patients. The total lack of data from randomised controlled trials is striking. The authors conclude that such trials, determining whether fibrinogen concentrate improves outcomes in prehospital management of trauma patients or whether fibrinogen concentrate is superior to another source of fibrinogen in early hospital management of trauma patients, are urgently warranted.

– Pär Johansson

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