The authors found that an early goal-directed fibrinogen substitution by fibrinogen concentrate was superior to the use of fresh frozen plasma in thoracic aortic repair, a clinical scenario with a high risk for bleeding and transfusion. Large volumes of plasma resulted in little improvement in haemostasis, with increased blood loss and transfusion requirements.

This small single-centre retrospective analysis is in line with current evidence and the ESA guidelines on the management of severe bleeding.

– Sibylle Kozek-Langenecker

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