Oct
2014

Monitoring of dabigatran anticoagulation and its reversal in vitro by thrombelastography.

Solbeck S, Meyer MA, Johansson PI, et al.
Int J Cardiol 2014;176:794-799.
NATA Rating :
Review by : B. J. Hunt
NATA Review

The authors investigated the in vitro effect of dabigatran on whole blood thromboelastography (TEG) and its reversal by recombinant activated factor VII (rFVIIa) and 4-factor prothrombin complex concentrate (PCC). Dabigatran changed all TEG parameters. There was little effect with PCC and some reversal with rFVIIa.

This paper adds to the literature on dabigatran reversal.

– Beverley J. Hunt