Hydroxyethyl starch 130/0.4 and the risk of acute kidney injury after cardiopulmonary bypass: a single-center retrospective study.

Lagny MG, Roediger L, Koch JN, et al.
J Cardiothorac Vasc Anesth 2016;30:869-875.
NATA Rating :
Review by : P. Van der Linden
NATA Review

This single-centre retrospective study reports a greater incidence of acute kidney injury (AKI) in the immediate postoperative period when balanced HES 130/0.4 versus a balanced crystalloid solution was used for pump prime and intraoperative fluid therapy in patients undergoing cardiac surgery with cardiopulmonary bypass.

The interpretation of these results is hampered by the fact that this effect on AKI (mainly AKI stage 1) disappeared at the 7th postoperative day and by the absence of long-term data on renal function in the studied population. Another potential limitation of this study is the absence of a protocol to guide intraoperative fluid administration.

– Philippe Van der Linden

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