Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial.

This trial is a non-inferiority RCT comparing the effect of a liberal versus restrictive transfusion strategy on health-related quality of life (HRQOL) in patients undergoing haematopoietic stem cell (HCT) transplant. The study focuses on HRQOL since multiple transfusion trials have already examined and shown no difference between a liberal versus restrictive transfusion strategy on mortality […]

Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study.

This study examines the association between postoperative anaemia and postoperative delirium. Given the high prevalence of postoperative anaemia, the authors were interested in understanding whether the lower oxygen delivery associated with anaemia would result in higher rates of postoperative delirium. This study was a secondary analysis of a previously done retrospective study. The study population […]

Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial.

In this multicentre, parallel-group, open-label, randomised trial, the authors compared the efficacy and safety of rivaroxaban versus standard anticoagulants in children 0-17 years with venous thromboembolism. Across 107 paediatric hospitals in 28 countries, children with documented acute venous thromboembolism (VTE) who had started heparin were assigned (2:1) to weight-adjusted rivaroxaban or standard anticoagulants (heparin or […]

Preterm neonates benefit from low prophylactic platelet transfusion threshold despite varying risk of bleeding or death.

The Platelets for Neonatal Thrombocytopenia (PlaNeT-2) trial, a multicentre randomised clinical trial, found an unexpected overall benefit of a prophylactic platelet transfusion threshold of 25 x 10^9/L compared to 50 x 10^9/L for major bleeding and/or mortality within 28 days of randomization in preterm neonates (7% absolute risk reduction). To assess if there was heterogeneity of treatment effect and […]

Fibryga® approved for acquired fibrinogen deficiency in Europe

New clinical data support efficacy of fibrinogen concentrate (fibryga®) in treating acquired fibrinogen deficiency and lead to label extension in Europe Fibrinogen replacement is widely accepted as an approach to managing acquired fibrinogen deficiency (AFD) in patients with critical bleeding, despite a lack of evidence until now from controlled clinical studies. Data from two comparative […]

Patient Blood Management is not about blood transfusion: it is about patients’ outcomes

In an editorial published in Blood Transfusion, Thomas Frietsch, Aryeh Shander, David Faraoni and Jean-Francois Hardy comment on the results of the Frankfurt Consensus Conference on Patient Blood Management (Müller MM et al. JAMA 2019;321:983-97). The conference produced ten clinical recommendations and twelve research statements relating to preoperative anaemia, red blood cell transfusion thresholds and implementation of PBM […]

Association between perinatal anemia and postpartum depression: A prospective cohort study of Japanese women.

Is there a relationship between anaemia and depression in the postpartum period? Certainly perioperative anaemia has been independently associated with increased morbidity and mortality across many different specialities in surgical and critical care. It has been linked to prolonged hospital length of stay, excessive health resource utilization and reduced disease-free survival. Maternal iron deficiency anaemia […]

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