Restrictive transfusion strategy after cardiac surgery.
Zeroual and colleagues report the results of a single-centre, single-blinded randomised controlled study of cardiac surgery patients comparing two strategies for transfusion of red blood cells. The control group followed […]
SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Surgical patients may be at high risk of venous thromboembolism (VTE). SARS‐CoV‐2 infection has been shown to increase this risk. In this huge international, multicentre, prospective cohort study of elective and emergency […]
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial.
Current approaches to trauma resuscitation focus on the timely control of bleeding and correction of trauma-induced coagulopathy using the administration of haemostatic therapy. Over the past decade, targeted and individualized […]
Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial.
Perioperative iron – There is no easy answer Intravenous (IV) iron is a major cornerstone of every PBM programme. It has been shown in many clinical situations that IV iron […]
Routine venous thromboembolism prophylaxis may be inadequate in the hypercoagulable state of severe coronavirus disease 2019.
This observationnal study has included 240 consecutive patients with confirmed severe acute respiratory syndrome coronavirus 2 infection admitted to one of three hospitals. One-hundred nine critically ill COVID 19 patients admitted […]
Effect of hydroxyethyl starch vs saline for volume replacement therapy on death or postoperative complications among high-risk patients undergoing major abdominal surgery: the FLASH randomized clinical trial.
There are few drugs that have gone through such a rollercoaster ride as hydroxyethyl starch (HES). While shortly after its introduction the belief still prevailed that all types of volume […]
Fibrinogen concentrate to cardiac surgery patients with ongoing bleeding does not increase the risk of thromboembolic complications or death.
In this retrospective, observational study, Waldén et al. describe the occurrence of thromboembolic events and mortality in cardiac surgery patients, depending on whether the patient had received fibrinogen supplementation. The […]
Effects of iron isomaltoside vs ferric carboxymaltose on hypophosphatemia in iron-deficiency anemia: two randomized clinical trials.
This article describes a new physiology via the upregulation of FGF23 by ferric carboxymaltose (FCM) with subsequent development of hypophosphatemia. It provides a degree of caution with the long-term use […]
Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial.
This trial is a non-inferiority RCT comparing the effect of a liberal versus restrictive transfusion strategy on health-related quality of life (HRQOL) in patients undergoing haematopoietic stem cell (HCT) transplant. […]
Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study.
This study examines the association between postoperative anaemia and postoperative delirium. Given the high prevalence of postoperative anaemia, the authors were interested in understanding whether the lower oxygen delivery associated […]
Improving preoperative haemoglobin using a quality improvement approach to treat iron deficiency anaemia.
In this article, the authors present their approach to the treatment of iron-deficiency anaemia in patients presenting for elective oesophagogastric surgery. These patients had a high incidence of preoperative anaemia […]
Variation in red cell transfusion practice in the intensive care unit – An international survey.
This study aimed to explore the variation in transfusion practice amongst critical care physicians using a cross-sectional online survey of critical care providers identified through the European Society of Intensive […]
Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial.
In this multicentre, parallel-group, open-label, randomised trial, the authors compared the efficacy and safety of rivaroxaban versus standard anticoagulants in children 0-17 years with venous thromboembolism. Across 107 paediatric hospitals […]
Preterm neonates benefit from low prophylactic platelet transfusion threshold despite varying risk of bleeding or death.
The Platelets for Neonatal Thrombocytopenia (PlaNeT-2) trial, a multicentre randomised clinical trial, found an unexpected overall benefit of a prophylactic platelet transfusion threshold of 25 x 10^9/L compared to 50 x 10^9/L for […]
Association of timing of plasma transfusion with adverse maternal outcomes in women with persistent postpartum hemorrhage.
Early plasma transfusion is believed to improve maternal outcomes in postpartum haemorrhage (PPH) because it could theoretically prevent or treat coagulopathy occurring among women treated for persistent PPH. However, as […]