Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial.
Perioperative iron – There is no easy answer Intravenous (IV) iron is a major cornerstone of every PBM programme. It has been shown in many clinical situations that IV iron […]
Effects of iron isomaltoside vs ferric carboxymaltose on hypophosphatemia in iron-deficiency anemia: two randomized clinical trials.
This article describes a new physiology via the upregulation of FGF23 by ferric carboxymaltose (FCM) with subsequent development of hypophosphatemia. It provides a degree of caution with the long-term use […]
Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial.
This trial is a non-inferiority RCT comparing the effect of a liberal versus restrictive transfusion strategy on health-related quality of life (HRQOL) in patients undergoing haematopoietic stem cell (HCT) transplant. […]
Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study.
This study examines the association between postoperative anaemia and postoperative delirium. Given the high prevalence of postoperative anaemia, the authors were interested in understanding whether the lower oxygen delivery associated […]
Improving preoperative haemoglobin using a quality improvement approach to treat iron deficiency anaemia.
In this article, the authors present their approach to the treatment of iron-deficiency anaemia in patients presenting for elective oesophagogastric surgery. These patients had a high incidence of preoperative anaemia […]
The association between iron-deficiency anemia and adverse pregnancy outcomes: a retrospective report from Pakistan.
This study is a retrospective study examining the association between maternal and neonatal outcomes and iron deficiency. While the authors note that the link between iron deficiency and adverse maternal […]
Incidence, duration, and management of anemia: a nationwide comparison between IBD and non-IBD populations.
This is a large database report of the incidence and duration of anaemia in the inflammatory bowel disease (IBD) population over the course of their disease lifetime. The authors conducted […]
Association between perinatal anemia and postpartum depression: A prospective cohort study of Japanese women.
Is there a relationship between anaemia and depression in the postpartum period? Certainly perioperative anaemia has been independently associated with increased morbidity and mortality across many different specialities in surgical […]
Prevalence of, associations with, and prognostic role of anemia in heart failure across the ejection fraction spectrum.
This study aims to establish a reliable prevalence estimate of anaemia in patients with different severities of heart failure (HF), and to identify whether the severity of HF and anaemia […]
Association between anemia and blood transfusion with long-term mortality following cardiac surgery.
This study by Padmanabhan et al. is a well-conducted retrospective analysis that confirms that anaemia before cardiac surgery is strongly associated with long-term mortality. The impact of preoperative anaemia seems […]
The impact of pre-operative intravenous iron on quality of life after colorectal cancer surgery: outcomes from the intravenous iron in colorectal cancer-associated anaemia (IVICA) trial.
In this follow-up of an open-label randomised controlled trial (designed to be pragmatic and applicable to current cancer treatment timelines, and powered to detect a difference in transfusion rates), the […]
The effect of anemia severity on postoperative morbidity among patients undergoing laparoscopic hysterectomy for benign indications.
This is a very well-designed retrospective study using a large American surgical database (NISQP) reporting the a high incidence of anaemia (19.5%) in patients undergoing elective laparoscopic hysterectomy. The following […]
Impact of a Patient Blood Management monitoring and feedback programme on allogeneic blood transfusions and related costs.
While Patient Blood Management (PBM) is becoming a new standard worldwide with evidence-based and expert consensus guidelines to promote the three PBM pillars, measuring the performance of these efforts remains […]
Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial.
Preoperative anaemia detection and the timely management of deficiencies remain a serious challenge in many health care settings. In this pragmatic RCT by Spahn et al., the trial design attempted […]
Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
This systematic review and meta-analysis focused on the implementation of a comprehensive PBM approach. Studies included had to address at least one recognised PBM modality per pillar. Data for 235,779 surgical […]