Characterizing the epidemiology of perioperative transfusion-associated circulatory overload.
The paper by Clifford et al. reports on the results of a very interesting retrospective study evaluating the epidemiology of transfusion-associated circulatory overload (TACO) in the specific setting of non-cardiac […]
Characterizing the epidemiology of postoperative transfusion-related acute lung injury.
TRALI is the leading cause of transfusion-related fatalities in the U.S. Estimates of incidence have ranged from 0.04 to 8.0% per transfused patient. Of note, a decline in the incidence […]
Serological and molecular evidence of a plausible transmission of hepatitis E virus through pooled plasma.
Transmission of hepatitis E virus (HEV) through blood products is still a matter of debate. Asymptomatic viremia has been reported in blood donors from several European countries and HEV transmission […]
Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors.
Iron supplementation in healthy blood donors to reduce donor deferral, iron deficiency and/or anaemia is a matter of debate. Blood donation inevitably results in the loss of about 250 mg of […]
Randomized study of washing 40- to 42-day-stored red blood cells.
This preliminary study compared the effectiveness of two different systems for RBC washing, a point-of-care device (Haemonetics Cell Saver Elite autotransfusion system) and a transfusion-service-based device (Terumo COBE 2991 cell […]
Prospective study on the clinical course and outcomes in transfusion-related acute lung injury.
Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion and has been the leading cause of transfusion-associated mortality over years. Two different types of TRALI have been […]
Counting platelets at transfusion threshold levels: impact on the decision to transfuse. A BEST Collaborative – UK NEQAS(H) International Exercise.
The authors conducted an international laboratory check survey for accuracy of determining platelet counts in thrombocytopenic patients (from 6.3 to 53 x 10(9)/L) and found significant variability in results. They conclude that […]
Perioperative transfusion-related acute lung injury: The Canadian Blood Services experience.
Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion. In immunogenic TRALI transfused donor antibodies – mostly from plasma products – are responsible for causing acute lung […]
Effects of pathogen reduction systems on platelet microRNAs, mRNAs, activation, and function.
Pathogen reduction (PR) of blood components improves the safety of modern haemotherapy. However, clinical studies have shown a loss of a portion of the PR-treated platelets resulting in an increased […]
The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units.
This interesting study examines the issue of “the storage lesion” in the critical setting of neonatal transfusion. It examines, in particular, the changes in iron and oxidative status of pediatric […]
Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia.
Washing of blood may be used to remove plasma proteins, electrolytes and cell debris from packed RBCs. Washing of RBCs reduces RBC recovery and is associated with the risk of […]
Transfusion-associated circulatory overload (TACO) and potential risk factors among the inpatient US elderly as recorded in Medicare administrative databases during 2011.
Transfusion-associated circulatory overload (TACO) is a serious complication of transfusion and an important differential diagnosis of transfusion-associated lung injury. TACO accounts for significant transfusion-related mortality, causing about 15% of all […]
Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation.
The impact of transfusion of fresh versus stored RBCs is still a matter of debate. In the present study, an ex vivo animal model was used, in which NO-mediated vasodilation […]
Effects of pre-storage leukoreduction on stored red blood cells signaling: A time-course evaluation from shape to proteome.
Leukocyte reduction of blood components significantly improves the quality of labile blood products by avoiding or reducing the transfusion-associated side effects of leukocytes such as febrile non-hemolytic transfusion reactions, transmission […]
Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: a prospective nested case-control study.
This is a very interesting and smart study. The study by Vlaar and colleagues helps us understand better what’s happening in TRALI patients. This large and prolonged prospective study elegantly […]