Oxygen delivery during extreme anemia with ultra-pure earthworm hemoglobin.
There’s life in the old dog yet! Although artificial oxygen carriers seemed to disappear out of sight from anemia research, a new approach with hemoglobin from the earthworm yields promising […]
Effects of fluid resuscitation with synthetic colloids or crystalloids alone on shock reversal, fluid balance, and patient outcomes in patients with severe sepsis: a prospective sequential analysis.
During three study periods, the authors compared the effects of the type of fluid resuscitation on the time to septic shock reversal and the development of acute kidney injury (AKI, […]
Red blood cell transfusion compared with gelatin solution and no infusion after cardiac surgery: effect on microvascular perfusion, vascular density, hemoglobin, and oxygen saturation.
This nonrandomized, prospective observational study evaluated oxygen transport and utilization following red blood cell (RBC) or gelatin transfusion for the correction of hypovolemia in 39 post-cardiac surgery patients, and compared […]
Hydroxyethyl starch or saline for fluid resuscitation in intensive care.
This multicenter prospective randomized double-blind study evaluated the safety and the efficacy of 6% HES 130/0.4 in saline compared to 0.9% saline alone for fluid resuscitation in an heterogenous population […]
Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis.
This multicenter, parallel-group, double-blind trial compared the effects of a balanced potato-derived tetrastarch solution (HES 130/0.42) and a balanced crystalloid solution (Ringer’s acetate) on 90-day mortality in patients with severe […]
The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs.
This study explores the influence of the type of plasma expander used to support extreme hemodilution on the critical hematocrit (blood hemoglobin concentration where total body oxygen consumption becomes dependent […]
Colloid solutions for fluid resuscitation.
This updated meta-analysis indicates that there is no evidence that one colloid solution is more effective or safe than any other and that larger trials of fluid therapy are required […]
Fluid management and risk factors for renal dysfunction in patients with severe sepsis and/or septic shock.
This French multicentric study evaluated the possible side effect on renal failure (need for renal replacement therapy) of the administration of HES 130/0.4 during the first 24 hours after admission in […]
The acute effects of acetate-balanced colloid and crystalloid resuscitation on renal oxygenation in a rat model of hemorrhagic shock.
In their rat hemorrhage model, the authors show that the use of a balanced colloid resuscitation regimen using acetate as a buffer resulted in a better restoration of renal oxygenation […]
Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients.
This manuscript reports consensus recommendations based on analysis of the literature (meta-analyses, systematic reviews and clinical studies) regarding the safety and efficacy of the colloids (hydroxyethyl starches [HES], gelatins and […]
Effects of crystalloid versus colloid and the alpha-2 agonist brimonidine versus placebo on intraocular pressure during prone spine surgery: a factorial randomized trial.
This factorial randomized trial evaluated the effects of two different treatments on intraocular pressure increases during prone spine surgery. The first treatment consisted in the administration of either 5% albumin […]
Boom or bust? Estimating blood demand and supply as the baby boomers age.
This editorial by Benjamin and Whitaker is well worth reading. It covers some familiar aspects of why there will always be continuing challenges to provide an adequate and safe blood […]
Effects of a combination hemoglobin based oxygen carrier-hypertonic saline solution on oxygen transport in the treatment of traumatic shock.
Despite several decades of concerted efforts of researchers worldwide, attempts to develop a safe and effective artificial oxygen carrier have not been successful yet. These disappointing results have reduced the […]
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
The authors have conducted a randomized controlled trial on the efficacy and safety of tranexamic acid in 100 patients undergoing total knee replacement surgery. They show that administration of tranexamic acid […]
Effect of routine iron supplementation with or without folic acid on anemia during pregnancy.
The authors conducted a systematic review of published randomized and quasi-randomized trials concerning the impact of iron and iron and folic acid supplementation on iron-deficiency anemia during pregnancy. In addition, […]