The association between iron-deficiency anemia and adverse pregnancy outcomes: a retrospective report from Pakistan.
This study is a retrospective study examining the association between maternal and neonatal outcomes and iron deficiency. While the authors note that the link between iron deficiency and adverse maternal […]
Incidence, duration, and management of anemia: a nationwide comparison between IBD and non-IBD populations.
This is a large database report of the incidence and duration of anaemia in the inflammatory bowel disease (IBD) population over the course of their disease lifetime. The authors conducted […]
Association between perinatal anemia and postpartum depression: A prospective cohort study of Japanese women.
Is there a relationship between anaemia and depression in the postpartum period? Certainly perioperative anaemia has been independently associated with increased morbidity and mortality across many different specialities in surgical […]
Four years’ experience of a ROTEM((R))-guided algorithm for treatment of coagulopathy in obstetric haemorrhage.
This important study by McNamara et al. reports on four years of observational data from a large UK hospital and tertiary referral unit, following the introduction of a rotational thromboelastometry-guided […]
Prevalence of, associations with, and prognostic role of anemia in heart failure across the ejection fraction spectrum.
This study aims to establish a reliable prevalence estimate of anaemia in patients with different severities of heart failure (HF), and to identify whether the severity of HF and anaemia […]
Tranexamic acid administration is not associated with an increase in complications in high-risk patients undergoing primary total knee or total hip arthroplasty: a retrospective case-control study of 38,220 patients.
This study was designed to examine whether tranexamic acid, which is a well-established therapy to reduce postoperative bleeding, is associated with adverse events in patients at high risk for a […]
Association between anemia and blood transfusion with long-term mortality following cardiac surgery.
This study by Padmanabhan et al. is a well-conducted retrospective analysis that confirms that anaemia before cardiac surgery is strongly associated with long-term mortality. The impact of preoperative anaemia seems […]
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery (DEPOSITION) study: Results of a pilot study.
The authors performed a pilot study comparing topical versus intravenous administration of tranexamic acid. Given the heterogeneity of cardiac surgery patients, the lack of any difference in outcome between the […]
Lack of persistent microchimerism in contemporary transfused trauma patients.
Jackman and colleagues evaluated transfusion-associated microchimerism (TA-MC) in a prospective cohort study of trauma patients. Index samples were collected upon admission, prior to transfusion and at periodical intervals up to […]
Transfusion practice in the non-bleeding critically ill: an international online survey-the TRACE survey.
In order to elucidate whether data from transfusion trials has impacted current intensive care transfusion management, de Bruin and colleagues performed an online, anonymous, worldwide survey among ICU physicians, evaluating […]
Impact of multidisciplinary pulmonary embolism response team availability on management and outcomes.
Chaudhury et al. retrospectively analysed the outcomes of 769 consecutive adult patients with pulmonary embolism (PE) (as diagnosed by computed tomography PE protocol) for the 18 months prior to and after initiation […]
The impact of pre-operative intravenous iron on quality of life after colorectal cancer surgery: outcomes from the intravenous iron in colorectal cancer-associated anaemia (IVICA) trial.
In this follow-up of an open-label randomised controlled trial (designed to be pragmatic and applicable to current cancer treatment timelines, and powered to detect a difference in transfusion rates), the […]
Association of blood component ratios with 24-hour mortality in injured children receiving massive transfusion.
While the incidence of paediatric trauma requiring massive transfusion is lower than the incidence in adults, little is known regarding the optimal transfusion strategy in the paediatric population. Although optimal […]
4-factor prothrombin complex concentrate is associated with improved survival in trauma related hemorrhage: a nationwide propensity matched analysis.
The authors conducted a retrospective study to evaluate outcomes of severely injured trauma patients who received 4-factor prothrombin complex concentrate (4-PCC) + fresh frozen plasma (FFP) compared to FPP alone. […]
Fibrinogen concentrate as an alternative to cryoprecipitate in a postcardiopulmonary transfusion algorithm in infants undergoing cardiac surgery: a prospective randomized controlled trial.
This is an excellent multicentre prospective randomised trial evaluating the efficacy of fibrinogen concentrate (FC) compared to cryoprecipitate to achieve haemostasis for infants post-cardiopulmonary bypass. The primary outcome was the […]