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Percutaneous radiofrequency (RF) ablation of liver tumors.

Chagnon and colleagues provide with detailed description of treatment approaches to liver cancer. They focus on the use of radiofrequency ablation of lesions coupled with ultrasonographic imaging as a guide to success. Their excellent discussion of options, inclusion and exclusion criteria and outcomes is well worth reading. Every general surgeon must be aware of the […]

Pharmacokinetics and safety of FFR-rFVIIa after single doses in healthy subjects.

This is a double-blind placebo controlled dose escalation trial evaluating efficacy and safety of inactivated rFVIIa (FFR-rFVIIa) as an antithrombotic agent. The trial showed a dose dependent prolongation of the prothrombin time. Future studies in patients undergoing vascular intervention are required. – M. Aldouri. FFR-rFVIIa is a variant activated factor VII molecule that is characterised […]

Heparin coating of the extracorporeal circuit combined with leukocyte filtration reduces coagulation activity, blood loss and blood product substitution.

Heparin bonded circuits have become standard in extracorporeal bypass circuits for open heart surgery. Leukoreduction of allogeneic red blood cells is also considered a standard of care in many countries. Martens and colleagues concluded from this small series of patients that the addition of a leukocyte filter to the heparin bonded circuit is associated with […]

Hepatocellular carcinoma treated with radiofrequency ablation: Comparison of pulse inversion contrast-enhanced harmonic sonography, contrast-enhanced power Doppler sonography, and helical CT.

Hepatitis C virus infects millions of people worldwide. As the world’s population ages, the incidence of Hepatitis C related hepatocellular carcinoma will increase. Any help in dealing with this lethal disease is most welcome. The authors discuss both minimally invasive approach to therapy with radiofrequency ablation and the use of various radiological techniques to assess […]

Liver resections with or without pedicle clamping.

The authors demonstrate in a well-thought-out study what we have all suspected based on trauma experience: that temporary clamping of the hepatic pedicle, or the Pringle manouver, can reduce blood loss and the need for transfusion without jeopardizing the patient. – R. K. Spence.

Hepatocellular carcinoma: Long-term results of combined treatment with laser thermal ablation and transcatheter arterial chemoembolization.

As the epidemic of hepatitis C-related liver disease slowly surfaces, physicians will be faced with the need to devise safe and effective ways other than liver resection and/or transplantation of treating patients with hepatocellular carcinoma. Pacella and colleagues show us how to effectively employ new technologies and minimally-invasive approaches in a collaborative effort that achieved […]