From the Literature

Published: Dec 2018

Krag M, Marker S, Perner A, et al.

Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU.
N Engl J Med 2018;379:2199-2208.

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NATA REVIEW:
This European multicentre trial randomised ICU patients to receive 40 mg of IV pantoprazole or placebo...
REVIEW by:
J. H. Levy

Published: Sep 2018

Mazer CD, Whitlock RP, Fergusson DA, et al.

Six-month outcomes after restrictive or liberal transfusion for cardiac surgery.
N Engl J Med 2018;379:1224-1233.

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NATA REVIEW:
In this follow-up article to the TRICS III trial, the authors report the clinical outcomes of moderate- to high-risk...
REVIEW by:
J.-F. Hardy

Published: Sep 2018

Goel R, Patel EU, Cushing MM, et al.

Association of perioperative red blood cell transfusions with venous thromboembolism in a North American registry.
JAMA Surg 2018;153:826-833

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NATA REVIEW:
An association between red blood cell (RBC) transfusion and increased incidence of perioperative complications...
REVIEW by:
D. Faraoni

Published: Aug 2018

Kuiper GJAJM, van Egmond LT, Henskens YMC, et al.

Shifts of transfusion demand in cardiac surgery after implementation of rotational thromboelastometry-guided transfusion protocols: analysis of the HEROES-CS observational, prospective open cohort database
J Cardiothorac Vasc Anesth 2018; Aug 29 [Epub ahead of print].

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NATA REVIEW:
In this study, Kuiper et al. compared outcome after cardiac surgery in terms of bleeding, rethoracotomies,...
REVIEW by:
H. B. Ravn

Published: Aug 2018

Sentilhes L, Winer N, Azria E, et al.

Tranexamic acid for the prevention of blood loss after vaginal delivery.
N Engl J Med 2018;379:731-742.

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NATA REVIEW:
This randomised controlled trial of tranexamic acid versus placebo in over 4,000 women after vaginal delivery...
REVIEW by:
B. J. Hunt

Published: Jun 2018

Myles PS, Bellomo R, Corcoran T, et al.

Restrictive versus liberal fluid therapy for major abdominal surgery.
N Engl J Med 2018;378:2263-2274.

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NATA REVIEW:
This article has the potential to influence or even to change current clinical fluid therapy during surgery,...
REVIEW by:
C. von Heymann

Published: May 2018

Sprigg N, Flaherty K, Appleton JP, et al.

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.
Lancet 2018;391:2107-2115.

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NATA REVIEW:
This paper shows that tranexamic acid given up to 8 hours after primary intracerebral haemorrhage reduced haematoma...
REVIEW by:
B. H. Hunt

Published: Apr 2018

Roubinian NH, Hendrickson JE, Triulzi DJ, et al.

Contemporary risk factors and outcomes of transfusion-associated circulatory overload.
Crit Care Med 2018;46:577-585.

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NATA REVIEW:
Recently, a joint working group of members of the International Haemovigilance Network, the International Society...
REVIEW by:
C. So-Osman

Published: Mar 2018

Hassan K, Bayer N, Schlingloff F, et al.

Bleeding complications after use of novel oral anticoagulants in patients undergoing cardiac surgery.
Ann Thorac Surg 2018;105:702-708.

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NATA REVIEW:
The authors evaluated 81 patients treated with non-vitamin K oral anticoagulants (NOACs) who underwent...
REVIEW by:
J. H. Levy

Published: Jan 2018

Gayet-Ageron A, Prieto-Merino D, Ker K, Shakur H, Ageron FX, Roberts I

Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40,138 bleeding patients.
Lancet 2018;391:125-132.

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NATA REVIEW:
Antifibrinolytic treatment has been shown to be effective in reducing blood loss and transfusion requirements...
REVIEW by:
M. Levi

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