From the Literature

Published: May 2019

Althoff FC, Neb H, Herrmann E, et al.

Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
Ann Surg 2019;269:794-804.

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NATA REVIEW:
This systematic review and meta-analysis focused on the implementation of a comprehensive PBM approach. Studies...
REVIEW by:
B. Froessler

Published: May 2019

Bhatt DL, Pollack CV, Weitz JI, et al.

Antibody-based ticagrelor reversal agent in healthy volunteers.
N Engl J Med 2019;308:1825-1833.

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NATA REVIEW:
Dual antiplatelet therapy (DAPT) is frequently used in patients with acute coronary syndrome, coronary stents,...
REVIEW by:
D. Faraoni

Published: May 2019

Habbab LM, Hussain S, Power P, et al.

Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery (DEPOSITION) study: Results of a pilot study.
J Card Surg 2019;34:305-311.

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NATA REVIEW:
The authors performed a pilot study comparing topical versus intravenous administration of tranexamic acid. Given...
REVIEW by:
H. B. Ravn

Published: Apr 2019

Connolly SJ, Crowther M, Eikelboom JW, et al.

Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors.
N Engl J Med 2019;380:1326-1335.

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NATA REVIEW:
Andexanet alfa, a recombinant inactive form of human factor Xa, was developed for reversal of factor Xa (FXa)...
REVIEW by:
J. H. Levy

Published: Feb 2019

Kuiper GJAJM, van Egmond LT, Henskens YMC, et al.

Shifts of transfusion demand in cardiac surgery after implementation of rotational thromboelastometry-guided transfusion protocols: analysis of the HEROES-CS observational, prospective open cohort database
J Cardiothorac Vasc Anesth 2019;33:307-317.

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NATA REVIEW:
In this study, Kuiper et al. compared outcome after cardiac surgery in terms of bleeding, rethoracotomies,...
REVIEW by:
H. B. Ravn

Published: Jan 2019

Curley A, Stanworth SJ, Willoughby K, et al.

Randomized trial of platelet-transfusion thresholds in neonates.
N Engl J Med 2019;380:242-251.

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NATA REVIEW:
In this multicentre trial, infants born at less than 34 weeks of gestation and in whom severe thrombocytopenia...
REVIEW by:
T. Haas

Published: Dec 2018

Krag M, Marker S, Perner A, et al.

Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU.
N Engl J Med 2018;379:2199-2208.

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NATA REVIEW:
This European multicentre trial randomised ICU patients to receive 40 mg of IV pantoprazole or placebo...
REVIEW by:
J. H. Levy

Published: Dec 2018

Goobie SM, Zurakowski D, Glotzbecker MP, et al.

Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial.
J Bone Joint Surg Am 2018;100:2024-2032.

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NATA REVIEW:
Posterior spinal fusion is a complex surgical procedure indicated to correct spinal deformation in idiopathic...
REVIEW by:
D. Faraoni

Published: Dec 2018

Ray WA, Chung CP, Murray KT, et al.

Association of oral anticoagulants and proton pump inhibitor cotherapy with hospitalization for upper gastrointestinal tract bleeding.
JAMA 2018;320:2221-2230.

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NATA REVIEW:
A huge study showing that during 754 389 person-years of anticoagulant treatment with apixaban, dabigatran,...
REVIEW by:
B. J. Hunt

Published: Sep 2018

Mazer CD, Whitlock RP, Fergusson DA, et al.

Six-month outcomes after restrictive or liberal transfusion for cardiac surgery.
N Engl J Med 2018;379:1224-1233.

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NATA REVIEW:
In this follow-up article to the TRICS III trial, the authors report the clinical outcomes of moderate- to high-risk...
REVIEW by:
J.-F. Hardy

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