From the Literature

Published: Apr 2019

Connolly SJ, Crowther M, Eikelboom JW, et al.

Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors.
N Engl J Med 2019;380:1326-1335.

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NATA REVIEW:
Andexanet alfa, a recombinant inactive form of human factor Xa, was developed for reversal of factor Xa (FXa)...
REVIEW by:
J. H. Levy

Published: Feb 2019

Kuiper GJAJM, van Egmond LT, Henskens YMC, et al.

Shifts of transfusion demand in cardiac surgery after implementation of rotational thromboelastometry-guided transfusion protocols: analysis of the HEROES-CS observational, prospective open cohort database
J Cardiothorac Vasc Anesth 2019;33:307-317.

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NATA REVIEW:
In this study, Kuiper et al. compared outcome after cardiac surgery in terms of bleeding, rethoracotomies,...
REVIEW by:
H. B. Ravn

Published: Jan 2019

Curley A, Stanworth SJ, Willoughby K, et al.

Randomized trial of platelet-transfusion thresholds in neonates.
N Engl J Med 2019;380:242-251.

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NATA REVIEW:
In this multicentre trial, infants born at less than 34 weeks of gestation and in whom severe thrombocytopenia...
REVIEW by:
T. Haas

Published: Dec 2018

Krag M, Marker S, Perner A, et al.

Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU.
N Engl J Med 2018;379:2199-2208.

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NATA REVIEW:
This European multicentre trial randomised ICU patients to receive 40 mg of IV pantoprazole or placebo...
REVIEW by:
J. H. Levy

Published: Dec 2018

Goobie SM, Zurakowski D, Glotzbecker MP, et al.

Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial.
J Bone Joint Surg Am 2018;100:2024-2032.

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NATA REVIEW:
Posterior spinal fusion is a complex surgical procedure indicated to correct spinal deformation in idiopathic...
REVIEW by:
D. Faraoni

Published: Dec 2018

Ray WA, Chung CP, Murray KT, et al.

Association of oral anticoagulants and proton pump inhibitor cotherapy with hospitalization for upper gastrointestinal tract bleeding.
JAMA 2018;320:2221-2230.

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NATA REVIEW:
A huge study showing that during 754 389 person-years of anticoagulant treatment with apixaban, dabigatran,...
REVIEW by:
B. J. Hunt

Published: Sep 2018

Goel R, Patel EU, Cushing MM, et al.

Association of perioperative red blood cell transfusions with venous thromboembolism in a North American registry.
JAMA Surg 2018;153:826-833

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NATA REVIEW:
An association between red blood cell (RBC) transfusion and increased incidence of perioperative complications...
REVIEW by:
D. Faraoni

Published: Aug 2018

Sentilhes L, Winer N, Azria E, et al.

Tranexamic acid for the prevention of blood loss after vaginal delivery.
N Engl J Med 2018;379:731-742.

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NATA REVIEW:
This randomised controlled trial of tranexamic acid versus placebo in over 4,000 women after vaginal delivery...
REVIEW by:
B. J. Hunt

Published: May 2018

Sprigg N, Flaherty K, Appleton JP, et al.

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.
Lancet 2018;391:2107-2115.

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NATA REVIEW:
This paper shows that tranexamic acid given up to 8 hours after primary intracerebral haemorrhage reduced haematoma...
REVIEW by:
B. H. Hunt

Published: Mar 2018

Hassan K, Bayer N, Schlingloff F, et al.

Bleeding complications after use of novel oral anticoagulants in patients undergoing cardiac surgery.
Ann Thorac Surg 2018;105:702-708.

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NATA REVIEW:
The authors evaluated 81 patients treated with non-vitamin K oral anticoagulants (NOACs) who underwent...
REVIEW by:
J. H. Levy

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